bs-1431R-BF350 [Conjugated Primary Antibody]
CK17/Cytokeratin 17 Polyclonal Antibody, AbBy Fluor-350 Conjugated
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Host: Rabbit

Target Protein: CK17/Cytokeratin 17

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3872

Source: KLH conjugated synthetic peptide derived from human Cytokeratin 17

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008].

Conjugation: AbBy Fluor-350

Excitation/ Emission: 346nm/442nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Liu Z et al.Ameliorative effects of a fusion protein dual targeting interleukin 17A and tumor necrosis factor α on imiquimod-induced psoriasis in mice.(2018) Biomedicine & Pharmacotherapy, 108, 1425–1435.Read more>>
  • Miss Hongfang Meng. et al. Overexpression of hepatocyte growth factor in dental pulp stem cells ameliorates the severity of psoriasis by reducing inflammatory responses. 2021 Jun 22Read more>>
  • Rosario Garca-Rocha. et al. Evidence that cervical cancer cells cultured as tumorspheres maintain high CD73 expression and increase their protumor characteristics through TGF- production. CELL BIOCHEM FUNCT. 2022 SepRead more>>
  • Jingwei Jiang. et al. The mechano-chemical circuit in fibroblasts and dendritic cells drives basal cell proliferation in psoriasis. CELL REP. 2024 Jul;43Read more>>
VALIDATION IMAGES