bs-14356R [Primary Antibody]
POLE2 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: DNA polymerase epsilon subunit 2

Immunogen Range: 101-200/527


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5427

Swiss Prot: P56282

Source: KLH conjugated synthetic peptide derived from human DNA Polymerase epsilon subunit 2

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Participates in DNA repair and in chromosomal DNA replication.

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
ICC(1:100-500)

Predicted Molecular Weight: 59


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Cow
Sheep
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Zhang Chuanjie. et al. Targeting POLE2 Creates a Novel Vulnerability in Renal Cell Carcinoma via Modulating Stanniocalcin 1. Front Cell Dev Biol. 2021 Feb;9:228Read more>>
  • Yongjun Zhu. et al. POLE2 knockdown reduce tumorigenesis in esophageal squamous cells. Cancer Cell Int. 2020 Dec;20(1):1-12Read more>>
  • Cong Lan. et al. Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction. EBIOMEDICINE. 2022 Aug;82:104139Read more>>
  • Sun Ming-yu. et al. POLE2 Regulates Apoptosis of Oral Squamous Cell Carcinoma Cells through the PI3K/AKT Signaling Pathway. CURR MED SCI. 2023 Dec;:1-11Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti-POLE2 Polyclonal Antibody, Unconjugated (bs-14356R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\n