Host: Rabbit
Target Protein: Gremlin 1
Immunogen Range: 101-184/184
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 26585
Swiss Prot: O60565
Source: KLH conjugated synthetic peptide derived from human gremlin 1
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Condition: Store at -20°C for 12 months..
Background: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity).
Size: 100ul
Concentration: 1ug/ul
Applications:
WB(1:300-1000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
Cross Reactive Species:
Mouse
Rat
Predicted Cross Reactive Species:
Human
Dog
Cow
Horse
Chicken
Rabbit
For research use only. Not intended for diagnostic or therapeutic use.
- Wellbrock, Jasmin, et al. "Overexpression of Gremlin-1 in Patients with Loeys-Dietz Syndrome: Implications on Pathophysiology and Early Disease Detection." PLoS one 9.8 (2014): e104742.Read more>>
- KAWAGUCHI, Kenichiro, et al. "Role of Gremlins in the Aortic Arch of Spontaneously Hypertensive and Hyperlipidemic Rats." The Showa University Journal of Medical Sciences 28.2 (2016): 89-99.Read more>>
Image kindly submitted by Dr. Wellbrock of the University Medical Center Hamburg-Eppendorf. Formalin-fixed and paraffin embedded human aortic tissue sections labeled with Rabbit Anti-Gremlin Polyclonal Antibody, Unconjugated (bs-1475R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti-gremlin Polyclonal Antibody (bs-1475R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
Formalin-fixed and paraffin embedded rat brain tissue labeled with Rabbit Anti-gremlin Polyclonal Antibody (bs-1475R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
Formalin-fixed and paraffin embedded rat small intestine tissue labeled with Rabbit Anti-gremlin Polyclonal Antibody (bs-1475R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.