bs-16767R

DATASHEET

Host: Rabbit

Target Protein: KLHL2

Immunogen Range: 1-100/593

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 11275

Swiss Prot: O95198

Source: KLH conjugated synthetic peptide derived from human KLHL2

Purification: purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

KLHL2 is a 593 amino acid actin-binding protein. Highly expressed in brain, KLHL2 is thought to play a role in the organization of the actin cytoskeleton in brain cells. KLHL3 (kelch-like protein 3), is a 587 amino acid protein active in the protein ubiquitination pathway. KLHL3 is thought to be a substrate-specific adapter of an E3 ubiquitin-ligase complex that mediates the ubiquitination of target proteins, which leads to proteasomal degradation of the target protein. KLHL2 and KLHL3 proteins contain six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function.

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:500-2000)
ELISA(1:5000-10000)
IHC-F(1:100-500)
IF(1:100-500)
IHC-P(1:100-500)

Predicted Molecular Weight: 66 kDa

Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.