bs-17137R-BF405

DATASHEET

Host: Rabbit

Target Protein: phospho-SP1 (Thr739)

Modification Site: Thr739

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6667

Swiss Prot: P08047

Source: KLH conjugated synthesised phosphopeptide derived from human SP1 around the phosphorylation site of Thr739

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.

Conjugation: AbBy Fluor-405

Excitation/ Emission: 401nm/421nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(ICC)(1:50-200)
IF(1:50-200)

Cross Reactive Species: Human
(African Green Monkey)

Predicted Cross Reactive Species: Cow
Horse
Monkey

For research use only. Not intended for diagnostic or therapeutic use.