DATASHEET
Host:
Rabbit
Target Protein:
GPR49/LGR5
Immunogen Range:
211-310/907
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
25406
Swiss Prot:
O75473
Source:
KLH conjugated synthetic peptide derived from human GPR49/LGR5
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Main cell surface receptor for hyaluronate. Adhesion to ucosal high endothelial venule and to types I and VI collagen. robably involved in matrix adhesion, lymphocyte activation and ymph node homing.
PRODUCT SPECIFIC PUBLICATIONS
- Liu Yahong. et al. Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003. Oxid Med Cell Longev. 2021;2021:6683836Read more>>
- Chaojie Li. et al. Hypoxia-induced Tie1 drives stemness and cisplatin resistance in non-small cell lung carcinoma cells. Cancer Cell Int. 2021 Dec;21(1):1-12Read more>>
- Ling Ding. et al. Bufalin Inhibits Tumorigenesis, Stemness, and Epithelial–Mesenchymal Transition in Colorectal Cancer through a C-Kit/Slug Signaling Axis. INT J MOL SCI. 2022 Jan;23(21):13354Read more>>
- Qi Yadong. et al. Heat-inactivated Bifidobacterium adolescentis ameliorates colon senescence through Paneth-like-cell-mediated stem cell activation. NAT COMMUN. 2023 Sep;14(1):1-19Read more>>
- Chengcheng Li. et al. LGR5, a prognostic stem cell target, promotes endometrial cancer proliferation through autophagy activation. TRANSL ONCOL. 2024 Feb;40:101853Read more>>
VALIDATION IMAGES
Lane 1: Mouse Brain lysates; Lane 2: Rat Brain lysates probed with LGR5 Polyclonal Antibody, Unconjugated (bs-20747R) at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C.
Lane 1: Mouse Cerebrum ysates; Lane 2: Mouse Stomach lysates; Lane 3: Mouse Colon lysates probed with GPR49/LGR5 Polyclonal Antibody, Unconjugated (bs-20747R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.