DATASHEET
Host:
Rabbit
Target Protein:
IL17A
Immunogen Range:
35-130/155
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
3605
Swiss Prot:
Q16552
Source:
KLH conjugated synthetic peptide derived from human IL-17
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background:
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
PRODUCT SPECIFIC PUBLICATIONS
- Niu, Yinghua, et al. "The balance between intrahepatic IL-17+ T cells and Foxp3+ regulatory T cells plays an important role in HBV-related end-stage liver disease." BMC immunology 12.1 (2011): 47.Read more>>
- Kou, Wei, et al. "Transforming growth factor-??1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment."Inflammation Research (2013): 1-7.2Read more>>
- Ghazi, H. F., N. A. Mohammed, and R. J. Hussein. "Tissue IL-17A expression associated with inflammatory lesions and ATG16L1 T300A allele in Crohn’s disease." International Journal of Advanced Research 3.1 (2015): 33-40.Read more>>
- Tang, Wei‑Jing, et al. "Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma." Oncology Letters.Read more>>
- Tang et al. Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma. (2017) Oncol.Lett. 14:561-568Read more>>
- Mangino G et al. Interleukin‐17A affects extracellular vesicles release and cargo in human keratinocytes. Exp Dermatol. 2019 Sep;28(9):1066-1073. Read more>>
- Haghighi Javid Asal. et al. IL-17A immune pattern across genetic acantholytic and blistering disorders. CLIN EXP DERMATOL. 2023 JaRead more>>
- Ettinger Monika. et al. Th17-associated cytokines IL-17 and IL-23 in inflamed skin of Darier disease patients as potential therapeutic targets. NAT COMMUN. 2023 Nov;14(1):1-1Read more>>
VALIDATION IMAGES
Paraformaldehyde-fixed, paraffin embedded Human Cervical Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with IL17A Polyclonal Antibody, Unconjugated (bs-2140R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human chronic tonsillitis; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with IL17A Polyclonal Antibody, Unconjugated (bs-2140R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.