bs-21429R-BF555 [Conjugated Primary Antibody]
CYP7A1 Polyclonal Antibody, AbBy Fluor-555 Conjugated
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Host: Rabbit

Target Protein: CYP7A1

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: P22680

Swiss Prot: 1581

Source: KLH conjugated synthetic peptide derived from human CYP7A1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010].

Conjugation: AbBy Fluor-555

Excitation/ Emission: 553nm/568nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Li S et al. Dietary Betaine Addition Promotes Hepatic Cholesterol Synthesis, Bile Acid Conversion, and Export in Rats. Nutrients. 2020 May 13;12(5):1399.Read more>>
  • Tan W et al. Pyrazinamide alleviates rifampin-induced steatohepatitis in mice by regulating the activities of cholesterol-activated 7-hydroxylase and lipoprotein lipase. Eur J Pharm Sci. 2020 Aug 1;151:105402.Read more>>
  • Wu P. et al. Arbutin Alleviates the Liver Injury of <i></i>-Naphthylisothiocyanate-induced Cholestasis Through Farnesoid X Receptor Activation.. Front Cell Dev Biol. 2021 Dec;9:758632-758632Read more>>
  • Dina Tawulie. et al. Jiang-Tang-San-Huang pill alleviates type 2 diabetes mellitus through modulating the gut microbiota and bile acids metabolism. PHYTOMEDICINE. 2023 Feb;:154733Read more>>
  • Li Xiao. et al. Kaempferol ameliorated alcoholic liver disease through inhibiting hepatic bile acid synthesis by targeting intestinal FXR-FGF15 signaling. PHYTOMEDICINE. 2023 Nov;120:155055Read more>>
  • Canye Li. et al. Gastrodin alleviates the deterioration of depressive-like behavior and glucolipid metabolism promoted by chronic stress in type 2 diabetic mice. EUR J PHARMACOL. 2024 Jun;973:176582Read more>>
  • Dongmei Qin. et al. Lupeol improves bile acid metabolism and metabolic dysfunction-associated steatotic liver disease in mice via FXR signaling pathway and gut-liver axis. BIOMED PHARMACOTHER. 2024 Aug;177:116942Read more>>
  • Fan Wu. et al. The cholesterol-lowering effects and mechanisms of novel milk casein-derived peptides in hyperlipidemia and hypercholesterol mice. FOOD BIOSCI. 2024 Oct;61:10473Read more>>
VALIDATION IMAGES