bs-2231R-Biotin [Conjugated Primary Antibody]
LYRIC Polyclonal Antibody, Biotin Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: LYRIC

Immunogen Range: 131-230/582


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 92140

Swiss Prot: Q86UE4

Source: KLH conjugated synthetic peptide derived from human AEG-1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 64


Cross Reactive Species: Human

Predicted Cross Reactive Species: Mouse
Rat
Dog
Cow
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Guo, Feng, et al. "Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis." Journal of Pediatric Urology (2013).Read more>>
  • Zheng, Jiasheng, et al. ʺAstrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune response.ʺ Tumor Biology (2013): 1-6.Read more>>
  • Guo, Jia, et al. "AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues." The Journal of Biomedical Research (2014).Read more>>
  • Zhang, Chun, et al. "MTDH/AEG-1-based DNA vaccine suppresses metastasis and enhances chemosensitivity to paclitaxel in pelvic lymph node metastasis."Biomedicine & Pharmacotherapy (2015).Read more>>
VALIDATION IMAGES