bs-22366R-Biotin [Conjugated Primary Antibody]
HLA-DR/HLA DRB1 Polyclonal Antibody, Biotin Conjugated
www.biossusa.com
[email protected]
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DATASHEET

Host: Rabbit

Target Protein: HLA-DR/HLA DRB1

Immunogen Range: 26-100/224


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3122

Swiss Prot: P01903

Source: KLH conjugated synthetic peptide derived from human HLA-DR/HLA DRB1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 29/25


Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.