bs-2334R-FITC [Conjugated Primary Antibody]
PXR Polyclonal Antibody, FITC Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: PXR

Immunogen Range: 51-150/434


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8856

Swiss Prot: O75469

Source: KLH conjugated synthetic peptide derived from human PXR

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

Conjugation: FITC

Excitation/ Emission: 494nm/518nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 48


Cross Reactive Species: Human
Mouse
Pig

Predicted Cross Reactive Species: Rat
Cow
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Sehirli, AO, et al. "St. Johns wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins."Journal of Physiology and Pharmacology 66.2 (2015): 203-214.Read more>>
  • Zhou, Xiaoqiao, et al. "Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway." Scientific Reports6 (2016): 27876.Read more>>
  • "Sun B et al. The interleukin-17 G-197A polymorphism is associated with cyclosporine metabolism and transplant rejection in liver transplant recipients. Pharmacogenomics. 2019 Feb 25."Read more>>
  • Mohandas S et al. Pregnane X receptor activation by its natural ligand Ginkgolide-A improves tight junction proteins expression and attenuates bacterial translocation in cirrhosis. Chem Biol Interact. 2019 Nov 4;315:108891. Read more>>
  • Desire Bartolini. et al. Alpha-Tocopherol Metabolites (The Vitamin E Metabolome) and Their Interindividual Variability during Supplementation. Antioxidants-Basel. 2021 Feb;10(2):173Read more>>
  • Xianyu Huang. et al. Transcriptome Analysis of Protection by Dendrobium Nobile Alkaloids (DNLA) against Chronic Alcoholic Liver Injury in Mice. BIOMEDICINES. 2022 Nov;10(11):28Read more>>
  • Shantong Qiu. et al. HNF4 improves hepatocyte regeneration by upregulating PXR. FASEB J. 2024 Jul;38(14):e2383Read more>>
VALIDATION IMAGES