bs-2377R [Primary Antibody]
CNR2/CB2 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CNR2/CB2

Specificity: May interact with Melanocortin receptor 4 in brain, placental, and gut tissues.

Immunogen Range: 251-350/360


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1269

Swiss Prot: P34972

Source: KLH conjugated synthetic peptide derived from human CNR2

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
FCM(1:20-100)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 40


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Xu A et al. Inhibiting effect of microRNA-187-3p on osteogenic differentiation of osteoblast precursor cells by suppressing cannabinoid receptor type 2. Differentiation. 2019 Jul 13;109:9-15. Read more>>
  • aban B et al. Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ. J Immunol Res. 2020 Feb 25;2020:6056373. Read more>>
  • aban B et al. Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ. J Immunol Res. 2020 Feb 25;2020:6056373. Read more>>
  • Nianbin Song. et al. Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence. Cell Immunol. 2020 Nov;357:10421Read more>>
  • T Coccini. et al. MAM-2201, One of the Most PotentNaphthoyl Indole DerivativeSynthetic Cannabinoids, Exerts Toxic Effects on Human Cell-Based Models of Neurons and Astrocytes. 2021 May 04Read more>>
  • Uliana De Simone. et al. Human Astrocyte Spheroids as Suitable In Vitro Screening Model to Evaluate Synthetic Cannabinoid MAM2201-Induced Effects on CNS. INT J MOL SCI. 2023 Jan;24(2):1421Read more>>
  • Meenakshi Ahluwalia. et al. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. EXP NEUROL. 2023 Jan;:11432Read more>>
  • Feng-Zhi Zhao. et al. Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells. INT IMMUNOPHARMACOL. 2023 Oct;123:110771Read more>>
  • Damla Zeynep Doyuran. et al. The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions. INT J BIOL MARKER. ;()Read more>>
  • Chen Jiayao. et al. Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene. OBES RES CLIN PRACT. 2023 NovRead more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-CNR2/CB2 Polyclonal Antibody, Unconjugated (bs-2377R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.


Formalin-fixed and paraffin embedded rat skin labeled with Anti-CNR2/CB2 Polyclonal Antibody, Unconjugated (bs-2377R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.


Lane 1: mouse lung lysates Lane 2: mouse brain lysates probed with Anti CNR2/CB2 Polyclonal Antibody, Unconjugated (bs-2377R) at 1:200 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in RT. Predicted band 40kD. Observed band size: 40kD.