bs-2392R [Primary Antibody]
Tau protein(Ser579) Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Tau protein Ser579

Modification Site: Ser579

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4137

Source: KLH conjugated synthetic phosphopeptide derived from human Tau protein isoform 2 around the phosphorylation site of Ser579

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IHC-P(1:200-400)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat
Bovine

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • An et al. Pharmacological Basis for Use ofArmillaria melleaPolysaccharides in Alzheimer's Disease: Antiapoptosis and Antioxidation. (2017) Oxid.Med.Cell.Longev. 2017:4184562Read more>>
  • Hu et al. Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis. (2018) Mol.Med.Rep.Nov;18(5):4289-4296. Read more>>
  • Yu H et al. Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis. Int J Mol Med. 2019 Mar;43(3):1406-1416.Read more>>
  • Qiao Xiang. et al. Anti-aging effect of Guanshan cherry blossom extract by regulating intestinal microbiota and activating glial cells. FOOD BIOSCI. 2023 Oct;55:103051Read more>>
  • Haitao Yu. et al. Pathological features and molecular signatures of early olfactory dysfunction in 3xTg-AD model mice. CNS NEUROSCI THER. 2024 Feb;30(2):e14632Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat brain labeled with Anti-phospho-Tau protein(Ser404)Polyclonal Antibody, Unconjugated (bs-2392R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.


Lane 1: SH-SY5Y cell lysates; Lane 2: MCF-7 cell lysates probed with Tau protein(Ser579) Polyclonal Antibody, Unconjugated (bs-2392) Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.


Lane 1: Mouse Cerebrum tissue lysates; Lane 2: Rat Cerebrum tissue lysates; Lane 3: Mouse Cerebellum tissue Lysates; Lane 4: Rat Cerebellum tissue Lysates; Lane 5: Human SH-SY5Y cell Lysates probed with phospho-Tau (Ser579) Polyclonal Antibody, Unconjugated (bs-2392R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.