bs-2399R [Primary Antibody]
CYP7A1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CYP7A1

Immunogen Range: 351-400/504


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1581

Swiss Prot: P22680

Source: KLH conjugated synthetic peptide derived from human CYP7A1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 55


Cross Reactive Species: Human
Mouse
Rat
(Rat)

Predicted Cross Reactive Species: Pig
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Wu, Hao, et al. "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." Phytomedicine (2014).Read more>>
  • Nukaya, Daiki, et al. "Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas." Genes to Cells(2015).Read more>>
  • Kou, Shuming, et al. "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." Life Sciences (2016).Read more>>
  • Gabbi, Chiara, et al. "Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease." Digestive and Liver Disease 44.12 (2012): 1018-1026.Read more>>
  • Guo, Hong-li, et al. "Pyrazinamide induced rat cholestatic liver injury through inhibition of FXR regulatory effect on bile acid synthesis and transport."Toxicological Sciences (2016): kfw098.Read more>>
  • Ding, Lin, et al. "Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism." Journal of Functional Foods 32 (2017): 90-97.Read more>>
  • Zhang, Jin-ming, et al. "Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells." Environmental Toxicology and Pharmacology (2017).Read more>>
  • Nukaya et al. Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas. (2015) Genes.Cells. 20:367-81Read more>>
  • Ma et al. Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats. (2017) Sci.Rep. 7:44819Read more>>
  • Zhong D. et al. Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF. (2018) Cellular Physiology and Biochemistry, 49(3):1163-1179.Read more>>
  • Zhong D et al. Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF.(2018)Cell Physiol Biochem.49(3):1163-1179. Read more>>
  • Shen X et al. Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice. Environ Int. 2019 Jul;128:146-157.Read more>>
  • Zhang L et al. Eicosapentaenoic acid in the form of phospholipid exerts superior anti-atherosclerosis effects than its triglyceride form in ApoE-/-mice. Food & Function. 2019  Read more>>
  • Wang N et al. Metabolite profiling of traditional Chinese medicine XIAOPI formula: An integrated strategy based on UPLC-Q-Orbitrap MS combined with network pharmacology analysis. Biomed Pharmacother. 2020 Jan;121:109569.Read more>>
  • Yu Z et al. Lipidomic Profiling Reveals the Effect of Egg Components on non\alcoholic Steatosis in HepG2 Cells and its Involved Mechanisms. European Journal of Lipid Science and Technology,2020, 1900451.Read more>>
  • Zhenya Zhai. et al. Policosanol alleviates hepatic lipid accumulation by regulating bile acids metabolism in C57BL6/mice through AMPKCFXRCTGR5 cross-talk. 2021 Nov 03Read more>>
  • Shinkichi Kosaka. et al. Birds eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes. J Steroid Biochem. 2022 Jul;221:106103Read more>>
  • Li Mei. et al. Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice. CHIN MED-UK. 2023 Dec;18(1):1-24Read more>>