bs-24450R-HRP [Conjugated Primary Antibody]
Polycystin 2 Polyclonal Antibody, HRP Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: Polycystin 2

Immunogen Range: 41-140/968


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5311

Swiss Prot: Q13563

Source: KLH conjugated synthetic peptide derived from human Polycystin 2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)

Predicted Molecular Weight: 106


Cross Reactive Species: Human

Predicted Cross Reactive Species: Mouse
Rat
Cow
Pig
Horse
Rabbit
Zebrafish

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES