bs-24606R-Biotin

DATASHEET

Host: Rabbit

Target Protein: HIF 2 alpha

Immunogen Range: 471-570/870

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2034

Swiss Prot: Q99814

Source: KLH conjugated synthetic peptide derived from human HIF 2 alpha

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100µL

Concentration: 1ug/ul

Applications: IHC-P(1:400-800)
IHC-F(1:400-800)

Predicted Molecular Weight: 96

Cross Reactive Species: Rat

Predicted Cross Reactive Species: Human
Pig

For research use only. Not intended for diagnostic or therapeutic use.