bs-2544R [Primary Antibody]
SLAMF7/CD319/CS1 Polyclonal Antibody
www.biossusa.com
[email protected]
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DATASHEET

Host: Rabbit

Target Protein: SLAMF7/CD319/CS1

Immunogen Range: 51-160/335


Clonality: Polyclonal

Isotype: IgG

Swiss Prot: Q9NQ25

Source: KLH conjugated synthetic peptide derived from human SLAMF7

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
FCM(1:20-100)

Predicted Molecular Weight: 33


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Cow

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Maekawa, T., et al. "Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis." Leukemia (2017).Read more>>
VALIDATION IMAGES

Mouse lymph node lysates probed with SLAMF7 Polyclonal Antibody, Unconjugated (bs-2544R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.