bs-2553R-A488 [Conjugated Primary Antibody]
CXCL13 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CXCL13/BCA1

Immunogen Range: 23-109/109


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 10563

Swiss Prot: O43927

Source: KLH conjugated synthetic peptide derived from human CXCL13

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

Conjugation: ALEXA FLUOR® 488

Excitation/ Emission: 490nm/525nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 10


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Dog

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Pei, Guangchang, et al. "Renal Interstitial Infiltration and Tertiary Lymphoid Organ Neogenesis in IgA Nephropathy." Clinical Journal of the American Society of Nephrology (2013): CJN-01150113.Read more>>
  • Pimenta, Erica Maria, et al. "IRF5 is a novel regulator of CXCL13 expression in breast cancer that regulates CXCR5+ B-and T-cell trafficking to tumor-conditioned media." Immunology and Cell Biology (2014).Read more>>
  • Nakamura, Kiwamu, et al. "Orosomucoid 1 drives opportunistic infections through the polarization of monocytes to the M2b phenotype." Cytokine 73.1 (2015): 8-15.Read more>>
  • Lemma, Siria A., et al. "Similar chemokine receptor profiles in lymphomas with central nervous system involvement–possible biomarkers for patient selection for central nervous system prophylaxis, a retrospective study." European Journal of Haematology (2015).Read more>>
  • Li, Congya, et al. "Up-regulation of chemokine CXCL13 in systemic candidiasis." Clinical Immunology (2017).Read more>>
  • Cao G et al. An imbalance between blood CD4+CXCR5+Foxp3+ Tfr cells and CD4+CXCR5+Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis. Mol Immunol. 2020 Sep;125:1-8.Read more>>
  • Gan Caoet al. An imbalance between blood CD4+ CXCR5+ Foxp3+ Tfr cells and CD4+ CXCR5+ Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis. Mol Immunol. 2020 Sep;125:1-8.Read more>>
  • Maria Chiara Trolese. et al. CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis. Ebiomedicine. 2020 Dec;62:103097Read more>>
VALIDATION IMAGES