bs-2624R [Primary Antibody]
IL-22R Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IL22RA1

Immunogen Range: 41-150/574


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 58985

Swiss Prot: Q8N6P7

Source: KLH conjugated synthetic peptide derived from human IL-22R

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)

Predicted Molecular Weight: 61


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Dog
Cow
Pig
Horse
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Guo, Yujie, et al. "IL-22-producing Th22 cells play a protective role in CVB3-induced chronic myocarditis and dilated cardiomyopathy by inhibiting myocardial fibrosis." Virology Journal 11.1 (2014): 2511.Read more>>
  • Zhang, Yan, and Mikhail G. Kolonin. "Cytokine signaling regulating adipose stromal cell trafficking." Adipocyte 5.4 (2016): 369-374.Read more>>
  • Kulkarni et al. Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. (2014) J.Am.Soc.Nephrol. 25:978-89Read more>>
  • Burgo et al. Ruxolitinib inhibits cyclosporine-induced proliferation of cutaneous squamous cell carcinoma. (2018) JCI.Insight. 3 Read more>>
  • Jane A. Lindborg. et al. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Rep. 2021 Mar;34:108777Read more>>
  • Wanzhen Li. et al. Ac2-26 attenuates hepatic ischemia-reperfusion injury in mice via regulating IL-22/IL-22R1/STAT3 signaling. PEERJ. 2022 Sep;10:e14086Read more>>
  • Yanan Hao. et al. Alginate Oligosaccharides Repair Liver Injury by Improving Anti-Inflammatory Capacity in a Busulfan-Induced Mouse Model. INT J MOL SCI. 2023 Jan;24(4):3097Read more>>
  • Jing Li. et al. Salidroside Inhibits Ganglion Cell Apoptosis by Suppressing the Mller Cell Inflammatory Response in Diabetic Retinopathy. CURR EYE RES. 2023 Jun 07Read more>>
  • Zhengchen Jiang. et al. IL-22 relieves hepatic ischemia-reperfusion injury by inhibiting mitochondrial apoptosis based on the activation of STAT3. INT J BIOCHEM CELL B. 2024 Jan;166:106503Read more>>
VALIDATION IMAGES

Lane 1: mouse liver lysates Lane 2: mouse intestine probed with Rabbit Anti-IL-22R Polyclonal Antibody, Unconjugated (bs-2624R) at 1:300 overnight at 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at RT.


Lane 1: Mouse placenta lysates probed with IL-22R Polyclonal Antibody, Unconjugated (bs-2624R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.