bs-2636R [Primary Antibody]
Integrin alpha 2b Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Integrin alpha 2b/CD41

Immunogen Range: 370-420/1033

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 16399

Swiss Prot: Q9QUM0

Source: KLH conjugated synthetic peptide derived from mouse Integrin alpha 2b

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

Storage Condition: Store at -20°C for 12 months.

Background: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Size: 100ul

Concentration: 1ug/ul

Applications: IHC-P(1:200-400)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Mei, Yun, et al. "The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation." Endocrinology (2013): en-2013.Read more>>
  • Araki, Tomoya, et al. "Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature." Journal of Controlled Release (2015).Read more>>
  • Lê, Vuong Ba, et al. "Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis." American Journal of Respiratory and Critical Care Medicine (2015).Read more>>
  • Sugiyama et al. Influenza Virus Infection Induces Platelet-Endothelial Adhesion Which Contributes to Lung Injury. (2016) J.Viro. 90:1812-23Read more>>