Host: Rabbit
Target Protein: Integrin alpha 2b/CD41
Immunogen Range: 370-420/1033
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 16399
Swiss Prot: Q9QUM0
Source: KLH conjugated synthetic peptide derived from mouse Integrin alpha 2b
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Condition: Store at -20°C for 12 months.
Background: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Size: 100ul
Concentration: 1ug/ul
Applications:
IHC-P(1:200-400)
IF(IHC-P)(1:50-200)
Cross Reactive Species:
Human
Mouse
Rat
For research use only. Not intended for diagnostic or therapeutic use.
- Mei, Yun, et al. "The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation." Endocrinology (2013): en-2013.Read more>>
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- Lê, Vuong Ba, et al. "Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis." American Journal of Respiratory and Critical Care Medicine (2015).Read more>>
- Sugiyama et al. Influenza Virus Infection Induces Platelet-Endothelial Adhesion Which Contributes to Lung Injury. (2016) J.Viro. 90:1812-23Read more>>