DATASHEET
Host:
Rabbit
Target Protein:
PGES2
Immunogen Range:
281-384/384
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
96979
Swiss Prot:
Q8BWM0
Source:
KLH conjugated synthetic peptide derived from mouse PGES2
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
PRODUCT SPECIFIC PUBLICATIONS
- Chia, Yuan-Yi, et al. "The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines." Pain Research and Management 2017 (2017).Read more>>
- Sutrisno, Sutrisno, et al. "The effect of genistein on TGF-β signal, dysregulation of apoptosis, cyclooxygenase-2 pathway, and NF-kB pathway in mice peritoneum of endometriosis model." Middle East Fertility Society Journal (2017).Read more>>
- Liu, Yun, et al. "Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection." Experimental Cell Research(2017).Read more>>
- MiKyung Song. et al. Saururus chinensis-controlled allergic pulmonary disease through NF-B/COX-2 and PGE2 pathways. 2020 Sep 24Read more>>
- Amy Tran-Guzman. et al. In vitro impact of genistein and mono(2-ethylhexyl) phthalate (MEHP) on the eicosanoid pathway in spermatogonial stem cells. Reprod Toxicol. 2022 Jan;107:15Read more>>
- Yu Liu. et al. Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats. OXID MED CELL LONGEV. 2022 Dec 09;2022:7727616Read more>>
- Nakatani Ayaka. et al. High-frequency near-infrared semiconductor laser irradiation suppressed experimental tooth movement-induced inflammatory pain markers in the periodontal ligament tissues of rats. LASER MED SCI. 2023 Dec;38(1):1-11Read more>>
- Dong Keon Oh. et al. Bifidobacterium longum BORI inhibits pain behavior and chondrocyte death, and attenuates osteoarthritis progression. PLOS ONE. 2023 Jun;18(6):e0286456Read more>>
VALIDATION IMAGES
HepG2 cells were fixed with 4% PFA for 10min at room temperature,permeabilized with 0.1% PBST for 20 min at room temperature, and incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with PTGES2 Antibody(bs-2639R)at 1:50 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2%BSA in PBS, followed by secondary antibody incubation for 40 min at room temperature. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).