bs-2653R-Biotin [Conjugated Primary Antibody]
SPHK2 Polyclonal Antibody, Biotin Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: SPHK2

Immunogen Range: 101-200/654


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 56848

Swiss Prot: Q9NRA0

Source: KLH conjugated synthetic peptide derived from human SPHK2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 72


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Zhang, Ruxin, et al. "Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway." Experimental and Molecular Pathology (2015).Read more>>
  • Tran, Hai B., et al. "Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720." Journal of Leukocyte Biology (2016): jlb-3A1015.Read more>>
  • Tani, Kohsuke, Keiji Tabuchi, and Akira Hara. "Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea."Neurotoxicity research 29.1 (2016): 35-46.Read more>>
  • Tran, Hai B., et al. "Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD." PloS one 12.11 (2017): e0179577.Read more>>
  • Mili Minaduola. et al. The circadian clock sets a spatialCtemporal window for recent thymic emigrants. IMMUNOL CELL BIOL. 2022 SepRead more>>
VALIDATION IMAGES