bs-2686R-PE

DATASHEET

Host: Rabbit

Target Protein: DKK3

Immunogen Range: 31-130/350

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 27122

Swiss Prot: Q9UBP4

Source: KLH conjugated synthetic peptide derived from human DKK3

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 36

Cross Reactive Species: Mouse
Rabbit

Predicted Cross Reactive Species: Human
Rat
Cow
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.