bs-2713R [Primary Antibody]
HAVCR1 Polyclonal Antibody
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Host: Rabbit

Target Protein: HAVCR1

Specificity: This antibody may also detect T cell immunoglobulin mucin-3 and HAVCR2 based upon an 80% sequential homology across the immunogen range.

Immunogen Range: 70-120/359


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 26762

Source: KLH conjugated synthetic peptide derived from human HAVCR1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IHC-P(1:200-400)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Oyagbemi AA et al. Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats.(2018)Environ Toxicol.Read more>>
  • Topdağı Ö et al. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life Sci. 2020 Feb 1;242:117217. Read more>>
  • Yao Y et al. Dexmedetomidine alleviates lipopolysaccharide-induced acute kidney injury by inhibiting the NLRP3 inflammasome activation via regulating the TLR4/NOX4/NF-κB pathway. J Cell Biochem. 2019 Oct;120(10):18509-18523.Read more>>
  • Zhu H et al. PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells. Cell Death Dis.2020 Dec 12;11(12):1057.Read more>>
  • Ademola Adetokunbo Oyagbemi. et al. Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-B/Kim-1 signaling in the heart and kidney of rats. Environ Toxicol Phar. 2020 Nov;80:103488Read more>>
  • Fang Wang. et al. Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis. Acta Pharmacol Sin. 2021 Apr;:1-12Read more>>
  • Jiang, Wenjuan. et al. Macrophage-derived, LRG1-enriched extracellular vesicles exacerbate aristolochic acid nephropathy in a TGFR1-dependent manner. 2021 Oct 22Read more>>
  • Wen-juan Jiang. et al. Tubular epithelial cell-to-macrophage communication forms a negative feedback loop via extracellular vesicle transfer to promote renal inflammation and apoptosis in diabetic nephropathy. Theranostics. 2022; 12(1): 324339Read more>>
  • Selim omakl. et al. Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB/p53 and Bcl-2 expression. 2022 Jan 17Read more>>
  • Ming-jun Yu. et al. Discovery of a Novel GRPR Antagonist for Protection against Cisplatin-Induced Acute Kidney Injury. BIOORG CHEM. Bioorg Chem. 2022 Apr;:105794Read more>>
  • Huang Yue-bo. et al. Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis. OXID MED CELL LONGEV. 2022;2022:4776243Read more>>
  • Glden Diniz. et al. Tissue Expression of Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Breast Cancers.. European Journal of Breast Health. 2022 Oct;18(4):336-342Read more>>
  • Pengmin Ji. et al. Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4CMAPK pathway in T2DM mice. RENAL FAILURE. 2023;45(1):Article: 2197075Read more>>
  • Xiao-yan He. et al. Cpd-42 Alleviates Acute Kidney Injury via Targeting RIPK3-mediated Necroptosis. BRIT J PHARMACOL. 2023 MayRead more>>
  • Xiao-cui Chen. et al. Asiatic acid alleviates cisplatin-induced renal fibrosis in tumor-bearing mice by improving the TFEB-mediated autophagy-lysosome pathway. BIOMED PHARMACOTHER. 2023 Sep;165:115122Read more>>
  • Qi Zhang. et al. Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling. TOXICOL MECH METHOD. 2023 Aug 31Read more>>
  • Xiaomei Luo. et al. Carnosine alleviates cisplatin-induced acute kidney injury by targeting Caspase-1 regulated pyroptosis. BIOMED PHARMACOTHER. 2023 Nov;167:115563Read more>>
  • Changlin Du. et al. PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation. ELIFE. 2024 FebRead more>>
  • Yufang Ni. et al. RfxCas13d-mediated inhibition of Circ1647 alleviates renal fibrosis via PI3K/AKT signaling pathway. RENAL FAILURE. 2024 Mar 25Read more>>
  • Xiaodan Li. et al. Effects of metaraminol and norepinephrine on hemodynamics and kidney function in a miniature pig model of septic shock. J TRANSL INTERN MED. 2024 Jun;12(3):253-262Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat testis labeled with Anti-HAVCR1 Polyclonal Antibody, Unconjugated (bs-2713R) at 1:200 followed by conjugation to the secondary antibody and DAB staining


Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti-HAVCR1 Polyclonal Antibody, Unconjugated (bs-2713R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.


Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-HAVCR1/TIM1/KM1 Polyclonal Antibody, Unconjugated(bs-2713R) at 1:200 followed by conjugation to the secondary antibody and DAB staining