DATASHEET
Host:
Rabbit
Target Protein:
Lyn
Specificity:
This protein is known to be similar in amino acid sequence to HCK. Therefore, cross-reactivity with this homologous protein may be observed
Immunogen Range:
201-300/512
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
4067
Swiss Prot:
P07948
Source:
KLH conjugated synthetic peptide derived from human Lyn
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
PRODUCT SPECIFIC PUBLICATIONS
- Iriyama et al. Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation. (2016) Cancer.Cell.Int. 16:37Read more>>
- Fu S et al. Berberine suppresses mast cell-mediated allergic responses via regulating FcɛRI-mediated and MAPK signaling.Int Immunopharmacol. 2019 Jun;71:1-6. Read more>>
- Xiangyu Liang. et al. Effects and potential mechanisms of Saposhnikovia divaricata (Turcz.) Schischk. On type I allergy and pseudoallergic reactions in vitro and in vivo. J ETHNOPHARMACOL. 2024 Jan;318:116942Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human glioma tissue labeled with Anti Lyn Polyclonal Antibody, PE conjugated (bs-2906R-PE) at 1:200 dilution for 60 minutes at 37°C.
Formalin-fixed and paraffin embedded human laryngocarcinoma labeled with Anti Lyn Polyclonal Antibody, PE conjugated (bs-2906R-PE) at 1:200 dilution for 60 minutes at 37°C.
Lane 1: Mouse SP2/0 cell lysates probed with Lyn Polyclonal Antibody, Unconjugated (bs-2906R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.
Lane 1: Mouse Lymph node tissue lysates; Lane 2: Mouse Lung tissue lysates; Lane 3: Mouse Placenta tissue lysates; Lane 4: Rat Lymph node tissue lysates ; Lane 5: Rat Placenta tissue lysates ; Lane 6: Human Raji cell lysates probed with Lyn Polyclonal Antibody, Unconjugated (bs-2906R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.