Target Protein: BLNK Tyr96
Modification Site: Tyr96
Entrez Gene: 29760
Swiss Prot: Q8WV28
Source: KLH conjugated synthetic phosphopeptide derived from human BLNK around the phosphorylation site of Tyr96 [DS(p-Y)EP]
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage: Store at -20°C for 12 months..
Background: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Predicted Molecular Weight: 50
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.