Target Protein: FAK Tyr397
Specificity: This phosphorylation site is homologous to that of Tyr428 in Mouse and Tyr397 in Rat.
Immunogen Range: 352-402/1052
Modification Site: Tyr397
Entrez Gene: 5747
Swiss Prot: Q05397
Source: KLH cunjugated synthetic phosphopeptide derived from human FAK 1 around the phosphorylation site of Tyr397
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Condition: Store at -20°C for 12 months.
Background: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.