bs-3253R [Primary Antibody]
LRP6 (Ser1490) Polyclonal Antibody
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]

Host: Rabbit

Target Protein: LRP6 Ser1490

Modification Site: Ser1490

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4040

Swiss Prot: O75581

Source: KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.


Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 175

Cross Reactive Species: Human

Predicted Cross Reactive Species: Dog

For research use only. Not intended for diagnostic or therapeutic use.

  • Chen, Zhidan, et al. "Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK‐LRP6 signalling." Journal of cellular and molecular medicine (2014).Read more>>
  • Boone, Jonathan D., et al. "Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974." Laboratory Investigation (2016).Read more>>
  • Yao,et al.LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics.(2017) Oncotarget. 8:109632-109645.Read more>>
  • Chen,et al.Immunogenicity and protective efficacy of recombinant fiber-2 protein in protecting SPF chickens against fowl adenovirus 4.(2018) Vaccine. 36:1203-1208.Read more>>
  • Xiao L et al. FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation. (2018) Bone Reports, 9, 136–144. Read more>>
  • Liu H et al. Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats. (2018) Phytother Res.Read more>>
  • Haixia Liu. et al. Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/\catenin signaling pathway in ovariectomized rats. Phytother Res. 2021 Jan;35(1):424-441Read more>>

Paraformaldehyde-fixed, paraffin embedded rat stomach; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with LRP6 (Ser1490) Polyclonal Antibody, Unconjugated (bs-3253R) at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining.