bs-3256R-PE

DATASHEET

Host: Rabbit

Target Protein: Phospho-Lyn (Tyr507)

Modification Site: Tyr508

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4067

Source: KLH conjugated synthetic phosphopeptide derived from human Lyn around the phosphorylation site of Tyr508

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Lyn (also known as p53/56 Lyn) is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL2 and IL3.

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Sheep
Pig
Horse
Chicken
Cat
Rabbit
Zebrafish
GuineaPig

For research use only. Not intended for diagnostic or therapeutic use.