bs-3306R

DATASHEET

Host: Rabbit

Target Protein: NMDAR2B Tyr1070

Specificity: This phosphorylated site is homologous to that of Tyr1070 in Mouse and Rat.

Modification Site: Tyr1070

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2904

Swiss Prot: Q13224

Source: KLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1070

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 164

Predicted Cross Reactive Species: Human
Mouse
Rat
Dog
Cow
Horse
Chicken

For research use only. Not intended for diagnostic or therapeutic use.