bs-3467R [Primary Antibody]
phospho-VEGF receptor 2 (Tyr1059) Polyclonal Antibody
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: phospho-VEGF receptor 2 (Tyr1059)

Modification Site: Tyr1059

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3791

Source: KLH conjugated synthetic phosphopeptide derived from human VEGF receptor 2 around the phosphorylation site of Tyr1059

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background:

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF()
Flow-Cyt(1ug/Test)

Predicted Molecular Weight: 147


Cross Reactive Species: Human
Mouse
Others

Predicted Cross Reactive Species: Rat
Dog
Cow
Pig
Horse
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yang Q et al. Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade. Cancer Manag Res. 2020 Jun 24;12:4937-4948.Read more>>
  • Zhu, Huaisen. et al. Ginsenoside Rg1 regulates thiram-induced chondrocytes apoptosis and angiogenesis in broiler chickens. ENVIRON SCI POLLUT R. 2022 Dec;:1-15Read more>>
VALIDATION IMAGES

HUVEC cell lysates probed with VEGF receptor 2 (Tyr1059) Polyclonal Antibody, Unconjugated (bs-3467R) at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.