bs-3533R-BF647

DATASHEET

Host: Rabbit

Target Protein: PLCG1

Immunogen Range: 1100-1150/1290

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5335

Source: KLH conjugated synthetic peptide derived from human PLC gamma 1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Conjugation: AbBy Fluor-647

Excitation/ Emission: 650nm/665nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Cow
Pig
GuineaPig

For research use only. Not intended for diagnostic or therapeutic use.