bs-3818R-HRP [Conjugated Primary Antibody]
GDF15/MIC-1 Polyclonal Antibody, HRP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: GDF15/MIC-1

Immunogen Range: 221-308/308


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9518

Swiss Prot: Q99988

Source: KLH conjugated synthetic peptide derived from human GDF-15

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 12.5/34


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Ruan, Wei-Min, et al. "Differential expression of glycoprotein non-metastatic melanoma protein B (GPNMB) involved in trichostatin A-induced apoptosis in gastric cancer." International journal of clinical and experimental medicine 7.12 (2014): 4857-4866.Read more>>
  • Figueiredo, Jose-Luiz, et al. "Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease." The American Journal of Pathology (2015).Read more>>
  • Li, Yun-Long, et al. "Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer." International Journal of Clinical and Experimental Pathology 8.7 (2015): 8136.Read more>>
  • Ueno, Koji, et al. "Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p." Scientific Reports 6 (2016): 36758.Read more>>
  • Falk, M., et al. "Biomechanical stress in myocardial infarctions: can endothelin-1 and growth differentiation factor 15 serve as immunohistochemical markers?." International Journal of Legal Medicine (2017): 1-10.Read more>>
  • Juan Zhang. et al. DHODH inhibition modulates glucose metabolism, circulating GDF15 and improves metabolic balance. Iscience. 2021 May;:102494Read more>>
  • Huan Li. et al. The Clinical Value of GDF15 and Its Prospective Mechanism in Sepsis. Front Immunol. 2021; 12: 710977Read more>>
  • Mengxue Zhang. et al. Identification and validation of potential novel biomarkers for oral squamous cell carcinoma. Bioengineered. 2021;12(1):8845-8862Read more>>
  • Xu Guanlan. et al. Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and Diabetes. ENDOCRINOLOGY. 2022 May;163(5)Read more>>
  • Sugimoto Mitsuru. et al. Clinical usefulness and acceleratory effect of macrophage inhibitory cytokine-1 on biliary tract cancer: an experimental biomarker analysis. CANCER CELL INT. 2022 Dec;22(1):1-15Read more>>
VALIDATION IMAGES