bs-4063R-A594 [Conjugated Primary Antibody]
HMGCR (Ser872) Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: HMGCR Ser872

Specificity: This phosphorylation site is homologous to that of Ser871 in Mouse and Rat.

Modification Site: Ser872

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3156

Swiss Prot: P04035

Source: KLH conjugated synthetic phosphopeptide derived from human HMGCR around the phosphorylation site of Ser872

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Conjugation: ALEXA FLUOR® 594

Excitation/ Emission: 590nm/617nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 97


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Pig
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Zanoni, Chiara, et al. "Investigations on the hypocholesterolaemic activity of LILPKHSDAD and LTFPGSAED, two peptides from lupin β-conglutin: Focus on LDLR and PCSK9 pathways." Journal of Functional Foods 32 (2017): 1-8.Read more>>
  • Zanoni, Chiara, et al. "Hempseed Peptides Exert Hypocholesterolemic Effects with a Statin-Like Mechanism." Journal of Agricultural and Food Chemistry (2017).Read more>>
  • Yang et al. HMG-CoA reductase is negatively associated with PCV2 infection and PCV2-induced apoptotic cell death. (2014) J.Gen.Viro. 95:1330-7Read more>>
  • Lammi et al. Hypocholesterolaemic Activity of Lupin Peptides: Investigation on the Crosstalk between Human Enterocytes and Hepatocytes Using a Co-Culture System Including Caco-2 and HepG2 Cells. (2016) Nutrients. 8 Read more>>
  • Lu L et al. The atheroprotective roles of heart-protecting musk pills against atherosclerosis development in apolipoprotein E-deficient mice. Ann Transl Med. 2019 Dec;7(23):714. Read more>>
  • Peng-Wei Yu. et al. EGCG Restricts PRRSV Proliferation by Disturbing Lipid Metabolism | Microbiology Spectrum. MICROBIOL SPECTR. 2022 ApRead more>>
  • Devendra Nath Tewari. et al. AMFR promotes innate immunity activation and proteasomal degradation of HMGCR in response to influenza virus infection in A549?cells. VIROLOGY. 2023 Oct;587:109875Read more>>
VALIDATION IMAGES