bs-41103P

DATASHEET

Entrez Gene: 9173

Swiss Prot: Q01638

Source: Recombinant human ST2 protein, N-His protein is expressed in E.coli with N-His. It contains the amino acid sequence of 19-328/556.

Storage Buffer: 20mM Tris-HCl (pH7.2) with 1M Urea.

Storage: The product should be stored at -70°C or -20°C.

Background:

ST2 is a member of a superfamily containing the Interleukin 1 (IL1) receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL1 receptor and Toll-like receptor 4 (TLR4) signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.

Sequence: 19-328/556

Size: 100µg, 500µg

Applications: ELISA

Mol. Wt.: 36

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.