bs-41239P
[Protein]
Recombinant human Lamin A/C protein, N-GST& C-His
DATASHEET
Entrez Gene: 4000
Swiss Prot: P02545
Source: Recombinant human Lamin A/C protein, N-GST& C-His protein is expressed in E.coli with N-GST&C-His. It contains the amino acid sequence of 26-198/664.
Storage Buffer: 0.01M TBS(pH7.4)
Storage: The product should be stored at -70°C or -20°C.
Background:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Size: 100ug,500ug
Applications: ELISA()
Mol. Wt.: 45
Species: Others
For research use only. Not intended for diagnostic or therapeutic use.