bs-41410P

DATASHEET

Source: An E.coli expression system produces recombinant Human ACE2 Protein, and the target gene encoding amino acids 243-369 is expressed with His Tag.

Storage Buffer: Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.

Storage: The product should be stored at -70°C or -20°C.

Background:

Angiotensin-converting enzyme 2 (ACE2) is an enzyme attached to the outer surface (cell membranes) of cells in the lungs, arteries, heart, kidney, and intestines. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1‚Äì7) (a vasodilator). ACE2 counters the activity of the related angiotensin-converting enzyme (ACE) by reducing the amount of angiotensin-II and increasing Ang(1-7) making it a promising drug target for treating cardiovascular diseases. ACE2 also serves as the entry point into cells for some coronaviruses including Severe acute respiratory syndrome coronavirus 2.

Endotoxin: Not Tested

Purity: >95% as determined by SDS-PAGE

Sequence: 18-615aa

Expression: E.coli

Tag: His tag

Size: 1mg,100ug

Applications: WB()
ELISA()

Mol. Wt.: 69.2kDa

Species: Human

For research use only. Not intended for diagnostic or therapeutic use.