bs-41432P
[Protein]
Recombinant SARS-CoV-2 Papain-Like Protease, N-His
DATASHEET
Entrez Gene: 43740578
Swiss Prot: P0DTD1
Source: Recombinant SARS-CoV-2 Papain-Like Protease, N-His protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1564-1880/7096.
Storage Buffer: 0.01M TBS(pH7.4)
Storage: The product should be stored at -70°C or -20°C.
Background:
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
Size: 100ug,500ug
Applications: ELISA()
Mol. Wt.: 35.8
Species: Others
For research use only. Not intended for diagnostic or therapeutic use.