bs-4151R [Primary Antibody]
PLCL1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: PLCL1

Specificity: This antibody may exhibit a slight secondary cross-reactivity with PLCL2 due to a 69% non-sequential sequence similarity over the immunogen range.

Immunogen Range: 1001-1096/1096


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5334

Source: KLH conjugated synthetic peptide derived from human PLCL1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

PLCL1 is involved an inositol phospholipid based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and sphatidylinositol. Component in the dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 123


Cross Reactive Species: Mouse

Predicted Cross Reactive Species: Human
Rat
Dog
Cow
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Luo, Shuai. et al. PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis. ADV RHEUMATOL. 2022 Dec;62(1):1-12Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-PLDL1 Polyclonal Antibody, Unconjugated (bs-4151R) at 1:200 followed by conjugation to the secondary antibody and DAB staining