bs-4197R-Cy5 [Conjugated Primary Antibody]
phospholamban Polyclonal Antibody, Cy5 Conjugated
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Host: Rabbit

Target Protein: phospholamban

Immunogen Range: 1-35/52


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5350

Source: KLH conjugated synthetic peptide derived from human phospholamban

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser-10, Ser-16, Thr-17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.

Conjugation: Cy5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 5.7


Predicted Cross Reactive Species: Human
Mouse
Rat
Cow
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Tao Liu. et al. Dapagliflozin attenuates cardiac remodeling and dysfunction in rats with -adrenergic receptor overactivation through restoring calcium handling and suppressing cardiomyocyte apoptosis. DIABETES VASC DIS RE. ;()Read more>>