bs-4198R-A647 [Conjugated Primary Antibody]
ETBR/Endothelin B Receptor Antibody, ALEXA FLUOR® 647 Conjugated
www.biossusa.com
[email protected]
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DATASHEET

Host: Rabbit

Target Protein: ETBR/Endothelin B Receptor

Immunogen Range: 378-442/442


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1910

Swiss Prot: P24530

Source: KLH conjugated synthetic peptide derived from human Endolin B Receptor

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Conjugation: ALEXA FLUOR® 647

Excitation/ Emission: 650nm/665nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 50


Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Cow
Pig
Horse
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Ji L et al. A high affinity nanobody against endothelin receptor type B: a new approach to the treatment of melanoma. Mol Biol Rep. 2020 Mar;47(3):2137-2147. Read more>>
  • Ravi Kumar. et al. Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cells. REDOX BIOL. 2022 Sep;55:102394Read more>>
  • Nataliia Hula. et al. The Long-Term Effects of Prenatal Hypoxia on Coronary Artery Function of the Male and Female Offspring. BIOMEDICINES. 2022 Dec;10(12):3019Read more>>
VALIDATION IMAGES