bs-42114P

DATASHEET

Entrez Gene: 8737

Swiss Prot: Q13546

Source: Recombinant human RIPK1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 327-564/671

Storage Buffer: 20mM Tris (pH8.0) with 8M Urea.

Storage: The product should be stored at -70°C or -20°C.

Background:

Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

Sequence: 327-564/671

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 28.7

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.