bs-42133P

DATASHEET

Entrez Gene: 8647

Swiss Prot: Q9QY30

Source: Recombinant mouse ABCB11 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 616-750/1321

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies, designated ABC1, Mdr/TAP, MRP, ALD, OABP, GCN20 and White. The secretion of bile salt molecules from blood into bile is a major driving force for bile formation. Bile salt export pump (BSEP) is a member of the Mdr/TAP subfamily of ABC transporters that mediates the transport of bile acids across the hepatocyte canalicular membrane and regulates bile acid-dependent bile secretion. BSEP contains putative phosphorylation sites for protein kinase A, protein kinase C (PKC) and Ca2+-calmodulin dependent kinase II, whose regulation may be dependent on bile salt concentration.

Sequence: 616-750/1321

Size: 100µg, 500µg, 20µg

Applications: Others

Mol. Wt.: 15

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.