bs-42139P

DATASHEET

Entrez Gene: 2634

Swiss Prot: P32456

Source: Recombinant human GBP2 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 50-306/591

Storage Buffer: 20mM Tris (pH8.0) with 8M Urea.

Storage: The product should be stored at -70°C or -20°C.

Background:

Guanylate-binding proteins, GBP1 and GBP2 are GTP-binding proteins with a high-turnover GTPase activity and an antiviral effect (1-4). GBP1 mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus and plays a role in the IFN-mediated antiviral response against these viruses (4). GBP1 and GBP2 belong to a group of large GTP-binding proteins with a high concentration-dependent GTPase activity that have the common ability to undergo oligomerization (1). GBP1 and GBP2 are bone marrow-derived GTPases encoded by interferon-activated genes and are inducible following IFN treatment (2,3). Specifically, GBP1 is expressed in cultured mammary epithelial tumor cell lines after treatment with IFN-gamma and LPS (5).

Sequence: 50-306/591

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 31.2

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.