bs-42194P

DATASHEET

Entrez Gene: 123264

Swiss Prot: Q86UW2

Source: Recombinant human OST-beta protein is expressed in E.coli with N-His. It contains the amino acid sequence of 57-128/128

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.

Sequence: 57-128/128

Size: 100ug, 500ug, 20ug

Applications: Others

Mol. Wt.: 35.5

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.