bs-42305P

DATASHEET

Entrez Gene: 81631

Swiss Prot: Q9GZQ8

Source: Recombinant human LC3B protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1-125/125

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.

Sequence: 1-125/125

Size: 100ug, 500ug, 20ug

Applications: Others

Mol. Wt.: 13

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.