bs-42341P

DATASHEET

Entrez Gene: 2475

Swiss Prot: P42345

Source: Recombinant human MTOR protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1-300/2549

Storage Buffer: 20mM Tris-HCl (pH8.0) with 2M Urea.

Storage: The product should be stored at -70°C or -20°C.

Background:

mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.

Sequence: 1-300/2549

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 36.1

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.