bs-42375P

DATASHEET

Entrez Gene: 3480

Swiss Prot: P08069

Source: Recombinant human IGF1R protein is expressed in E.coli with N-Trx-His. It contains the amino acid sequence of 741-932/1367

Storage Buffer: 20mM Tris-Hcl (pH=8.0) with 2M Urea

Storage: The product should be stored at -70°C or -20°C.

Background:

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Sequence: 741-932/1367

Size: 100ug, 500ug

Applications: Others

Mol. Wt.: 24.3

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.