bs-42393P

DATASHEET

Entrez Gene: 17123

Swiss Prot: Q61826

Source: Recombinant mouse MADCAM1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 22-364/405

Storage Buffer: 20mM Tris-Hcl (pH=8.0) with 8M Urea

Storage: The product should be stored at -70°C or -20°C.

Background:

The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer’s patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin Alpha 4/Beta 7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis.

Sequence: 22-364/405

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 40.7

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.