bs-42399P

DATASHEET

Entrez Gene: 246

Swiss Prot: P16050

Source: Recombinant mouse ALOX15 protein is expressed in E.coliwith N-His. It contains the amino acid sequence of 2-226/663

Storage Buffer: 20mM Tris-Hcl (pH=8.0) with 8M Urea and 0.1M L-Arg

Storage: The product should be stored at -70°C or -20°C.

Background:

Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.

Sequence: 2-226/663

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 30

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.